Full Schedule

08:00 – 09:25 CEST

Session XI: Presentation of Selected Abstracts: Colorectal Cancer

Chair: Fortunato Ciardiello, MD, PhD – Università degli Studi della Campania Luigi Vanvitelli

Chair: Juan Manuel O'Connor, MD, MSc – Instituto Alexander Fleming

08:00 – 08:08 CEST

SO-17: A new risk classification integrating ctDNA, CEA and pTN stage for DFS prognosis and predictive value for treatment duration in stage III colon cancer

Abstract Presenter: Thomas Samaille

Favorite

08:08 – 08:16 CEST

SO-18: ctDNA-guided adjuvant treatment after radical intent treatment of metastatic spread from colorectal cancer is feasible – results from the preplanned interim analysis of the OPTIMISE Study

Abstract Presenter: Louise Callesen

Favorite

08:16 – 08:24 CEST

SO-19: The outcome of resected stage II colon cancer patients with deficient mismatch repair T4 tumors: A national cancer database analysis

Abstract Presenter: Sakti Chakrabarti

Favorite

08:24 – 08:34 CEST

Discussant: SO-17, SO-18, SO-19

Discussant: Per Pfeiffer – Odense University Hospital

Favorite

08:34 – 08:44 CEST

O-8: Somatic and germline heterogeneity across colorectal cancer patient characteristics: Implications for early cancer detection

Abstract Presenter: Jeffrey Weitzel

Favorite

08:44 – 08:52 CEST

SO-20: The landscape Of homologous recombination deficiency in colorectal cancer

Abstract Presenter: Muhammad Danyal Ahsan

Favorite

08:52 – 09:00 CEST

SO-21: Tumor mutational signatures in early-onset versus average-onset colorectal cancer

Abstract Presenter: Eric Lander

Favorite

09:00 – 09:08 CEST

SO-34: Multi-label transcriptional classification of colorectal cancer reflects tumour cell population heterogeneity

Abstract Presenter: Enzo Medico

Favorite

09:08 – 09:25 CEST

Discussant: O-8, SO-20, SO-21, SO-34

Discussant: Pierre Laurent-Puig, MD. PhD – Université Paris Cité

Favorite

08:00 – 09:25 CEST

Session XII: Minisymposium: The Role of Functional Imaging in GI Cancer

Chair: Christophe M. Deroose, Prof. Dr. – University Hospitals Leuven / KU Leuven

Chair: Radka Obermannova, MD, PhD – Masaryk Memorial Cancer Institute and Masaryk University

Favorite

08:00 – 08:20 CEST

Intriguing Cases on Imaging

Panelist: Christophe M. Deroose, Prof. Dr. – University Hospitals Leuven / KU Leuven

Panelist: Raquel Perez-Lopez, MD, PhD – Vall d'Hebron Institute of Oncology

Favorite

08:20 – 08:40 CEST

PET/CT

Speaker: Christophe M. Deroose, Prof. Dr. – University Hospitals Leuven / KU Leuven

Favorite

08:40 – 09:00 CEST

Radiomics in GI Cancer

Speaker: Raquel Perez-Lopez, MD, PhD – Vall d'Hebron Institute of Oncology

Favorite

09:00 – 09:25 CEST

Q&A and Panel Discussion

Moderator: Christophe M. Deroose, Prof. Dr. – University Hospitals Leuven / KU Leuven

Moderator: Radka Obermannova, MD, PhD – Masaryk Memorial Cancer Institute and Masaryk University

Panelist: Raquel Perez-Lopez, MD, PhD – Vall d'Hebron Institute of Oncology

Favorite

08:00 – 09:25 CEST

Session XIII: GI Cancer in Elderly: Challenges and Prospects (includes IO in elderly)

Favorite

08:00 – 08:15 CEST

Geriatric Factors and Outcomes

Speaker: Demetris Papamichael, MB BS FRCP – Bank of Cyprus Oncology Centre

Favorite

08:15 – 08:35 CEST

Management of Upper GI Cancers in the Elderly

Speaker: Sylvie Lorenzen – Klinikum rechts der Isar, Technical University Munich

Favorite

08:35 – 08:55 CEST

Management of Colorectal Cancer in the Elderly – Adjuvant Therapy

Speaker: Emmanuel Mitry, MD PhD – Institut Paoli-Calmettes

Favorite

08:55 – 09:15 CEST

Immunotherapy for GI Cancers in the Elderly

Speaker: Naureen Starling, BSc(Hons) MBBS MD(Res) FRCP – The Royal Marsden Hospital

Favorite

09:15 – 09:25 CEST

Q&A and Panel Discussion

Moderator: Cathy Eng, MD, FACP, FASCO – Vanderbilt-Ingram Cancer Center

Moderator: Demetris Papamichael, MB BS FRCP – Bank of Cyprus Oncology Centre

Panelist: Emmanuel Mitry, MD PhD – Institut Paoli-Calmettes

Panelist: Sylvie Lorenzen – Klinikum rechts der Isar, Technical University Munich

Panelist: Naureen Starling, BSc(Hons) MBBS MD(Res) FRCP – The Royal Marsden Hospital

Favorite

08:00 – 09:25 CEST

Session XIV: WCGIC: Molecular Marker Platforms: Focus on Liquid Biopsies

Chair: Pierre Laurent-Puig, MD. PhD – Université Paris Cité

Chair: Clara Montagut, MD, PhD – Hospital del Mar

Chair: Josep Tabernero, MD – Vall d’Hebron University Hospital

Favorite

08:00 – 09:25 CEST

Precision Medicine Development in Gastrointestinal Oncology: Evidence-Based Guidelines Using Liquid Biopsies in Treatment, Decision Making, Optimizing Management, and Sequencing

Panelist: Jeanne Tie, MBChB FRACP MD – Peter MacCallum Cancer Centre

Panelist: Christelle de la Fouchardière – Institut Paoli-Calmettes

Panelist: Filippo Pietrantonio, Dr – Fondazione IRCCS Istituto Nazionale dei Tumori

Panelist: Dirk Arnold, MD PhD – Asklepios Tumorzentrum Hamburg

Favorite

09:30 – 10:30 CEST

Session XV: Emerging Targets in GI Cancer

Chair: Fatima Carneiro, MD, PhD – Institute of Pathology and Molecular Immunology of the University of Porto (IPATIMUP)

Chair: Eric Van Cutsem, MD, PhD – University Hospitals Leuven / KU Leuven

Favorite

09:30 – 09:50 CEST

Targeting RAS Mutations

Speaker: John Strickler, MD – Duke University

Favorite

09:50 – 10:10 CEST

Targeting the HER2 Pathway in GI Cancer

Speaker: Valentina Gambardella, MD, PhD – Hospital Clínico Valencia

Favorite

10:10 – 10:30 CEST

Targeting Claudin 18.2 in GI Cancer

Speaker: Radka Obermannova, MD, PhD – Masaryk Memorial Cancer Institute and Masaryk University

Favorite

10:30 – 11:00 CEST

Break and Poster Viewing

Favorite

10:35 – 10:55 CEST

Poster Discussion Guided Tours - Group 7: Colon Cancer I (PD-18, PD-19, PD-20)

Poster Discussant: Erika Martinelli, MD, PhD – Università degli Studi della Campania Luigi Vanvitelli

Favorite

10:35 – 10:55 CEST

Poster Discussion Guided Tours - Group 8: Colon Cancer II (PD-21, PD-22, PD-23, PD-24)

Poster Discussant: Pierre Laurent-Puig, MD. PhD – Université Paris Cité

Favorite

11:00 – 13:15 CEST

Session XVI: Rectal Cancer

Chair: André JL D'Hoore, MD, PhD – University Hospitals Leuven / KU Leuven

Chair: Erika Martinelli, MD, PhD – Università degli Studi della Campania Luigi Vanvitelli

Favorite

11:00 – 11:20 CEST

MRI: New Data and Learnings in Rectal Cancer

Speaker: Gina Brown, MD – Imperial College

Favorite

11:20 – 11:28 CEST

A Critical Reappraisal of an Optimal TNT Strategy by an MDT: A Surgeon’s Viewpoint

Speaker: André JL D'Hoore, MD, PhD – University Hospitals Leuven / KU Leuven

Favorite

11:28 – 11:36 CEST

A Critical Reappraisal of an Optimal TNT Strategy by an MDT: A Medical Oncologist’s Viewpoint

Speaker: Jeroen Dekervel, MD, PhD – University Hospitals Leuven / KU Leuven

Favorite

11:36 – 11:44 CEST

A Critical Reappraisal of an Optimal TNT Strategy by an MDT: A Radiation Oncologist’s Viewpoint

Speaker: Karin Haustermans, MD, PhD – University Hospitals Leuven / KU Leuven

Favorite

11:44 – 11:55 CEST

A Critical Reappraisal of an Optimal TNT Strategy by an MDT: Q&A and Panel Discussion

Moderator: André JL D'Hoore, MD, PhD – University Hospitals Leuven / KU Leuven

Moderator: Erika Martinelli, MD, PhD – Università degli Studi della Campania Luigi Vanvitelli

Panelist: André JL D'Hoore, MD, PhD – University Hospitals Leuven / KU Leuven

Panelist: Jeroen Dekervel, MD, PhD – University Hospitals Leuven / KU Leuven

Panelist: Karin Haustermans, MD, PhD – University Hospitals Leuven / KU Leuven

Panelist: Florence Huguet, Professor – Hôpital Tenon, AP-HP, Sorbonne Université

Panelist: Rodrigo O. Perez, MD, PhD – Hospital Alemão Oswaldo Cruz

Panelist: Lucjan Wyrwicz, MD PhD – Maria Sklodowska-Curie National Cancer Research Institute

Favorite

André JL D'Hoore, MD, PhD (he/him/his) – University Hospitals Leuven / KU Leuven ### 1004014###Moderator###chair department###University Hospitals Leuven / KU Leuven###
Moderator: André JL D'Hoore, MD, PhD (he/him/his) – University Hospitals Leuven / KU Leuven
### he/him/his @@@ Erika Martinelli, MD, PhD – Università degli Studi della Campania Luigi Vanvitelli ### 748613###Moderator###Associate Professor###Università degli Studi della Campania Luigi Vanvitelli###
Moderator: Erika Martinelli, MD, PhD – Università degli Studi della Campania Luigi Vanvitelli
### @@@ André JL D'Hoore, MD, PhD (he/him/his) – University Hospitals Leuven / KU Leuven ### 1004014###Panelist###chair department###University Hospitals Leuven / KU Leuven###
Panelist: André JL D'Hoore, MD, PhD (he/him/his) – University Hospitals Leuven / KU Leuven
### he/him/his @@@ Jeroen Dekervel, MD, PhD (he/him/his) – University Hospitals Leuven / KU Leuven ### 1961402###Panelist###Associate Professor###University Hospitals Leuven / KU Leuven###
Panelist: Jeroen Dekervel, MD, PhD (he/him/his) – University Hospitals Leuven / KU Leuven
### he/him/his @@@ Karin Haustermans, MD, PhD (she/her/hers) – University Hospitals Leuven / KU Leuven ### 1320049###Panelist###Radiation oncologist###University Hospitals Leuven / KU Leuven###
Panelist: Karin Haustermans, MD, PhD (she/her/hers) – University Hospitals Leuven / KU Leuven
### she/her/hers @@@ Florence Huguet, Professor (she/her/hers) – Hôpital Tenon, AP-HP, Sorbonne Université ### 1664396###Panelist###Head of Radiation Oncology department###Hôpital Tenon, AP-HP, Sorbonne Université###
Panelist: Florence Huguet, Professor (she/her/hers) – Hôpital Tenon, AP-HP, Sorbonne Université
### she/her/hers @@@ Rodrigo O. Perez, MD, PhD – Hospital Alemão Oswaldo Cruz ### 716626###Panelist###Chair, Colorectal Surgical Oncology Service###Hospital Alemão Oswaldo Cruz###
Panelist: Rodrigo O. Perez, MD, PhD – Hospital Alemão Oswaldo Cruz
### @@@ Lucjan Wyrwicz, MD PhD (he/him/his) – Maria Sklodowska-Curie National Cancer Research Institute ### 1666061###Panelist###Head of Dept of Oncology and Radiotherapy###Maria Sklodowska-Curie National Cancer Research Institute###
Panelist: Lucjan Wyrwicz, MD PhD (he/him/his) – Maria Sklodowska-Curie National Cancer Research Institute
### he/him/his

11:55 – 12:10 CEST

Surveillance in Non-Operative Management/Watch & Wait Strategy: How to do?

Speaker: Rodrigo O. Perez, MD, PhD – Hospital Alemão Oswaldo Cruz

Favorite

12:10 – 12:30 CEST

Flash: How to Integrate CPI in MSI-H Rectal Cancer: Double CPI? Duration? Role of RT?

Speaker: Thierry André, MD – Hopital Saint Antoine

Favorite

12:20 – 12:30 CEST

Flash: Is Robotic Surgery Taking off in Rectal Cancer

Speaker: Jim Khan, MD, PhD, FRCS – University of Portsmouth, Portsmouth Hospitals University NHS Trust

Favorite

12:30 – 12:45 CEST

The Challenge of Lateral Lymph Nodes

Speaker: George Chang, MD, MSc – MD Anderson Cancer Center, The University of Texas

Favorite

12:45 – 13:15 CEST

Challenging Cases in Rectal Cancer

Moderator: André JL D'Hoore, MD, PhD – University Hospitals Leuven / KU Leuven

Moderator: Erika Martinelli, MD, PhD – Università degli Studi della Campania Luigi Vanvitelli

Panelist: Irit Ben-Aharon, MD, PhD – Rambam Health Care Campus

Panelist: George Chang, MD, MSc – MD Anderson Cancer Center, The University of Texas

Panelist: Florence Huguet, Professor – Hôpital Tenon, AP-HP, Sorbonne Université

Panelist: Rodrigo O. Perez, MD, PhD – Hospital Alemão Oswaldo Cruz

Favorite

13:15 – 13:30 CEST

Break

Favorite

13:30 – 15:00 CEST

Lunch Symposium: In the Medical Spotlight: Antibody-Drug Conjugates in Advanced HER2-Positive Gastric/ Gastroesophageal Junction Cancer Supported by Daiichi Sankyo

Favorite

13:30 – 15:00 CEST

Lunch Symposium: New Hope for Metastatic Pancreatic Cancer Patients Supported by Servier International Medical Affairs

Favorite

13:30 – 15:00 CEST

Lunch Symposium: Putting the Pieces Together to Optimise the Management of BRAF V600E-mutant mCRC Supported by Pierre Fabre

Favorite

13:30 – 15:00 CEST

Lunch Symposium: Value of Disease Stabilization Across GI Tumors Supported by Bayer

Favorite

15:15 – 16:40 CEST

Session XVII: Adjuvant and Neoadjuvant Treatment of Colon Cancer

Chair: John L. Marshall, MD – Lombardi Comprehensive Cancer Center, Georgetown University

Chair: Eric Van Cutsem, MD, PhD – University Hospitals Leuven / KU Leuven

Favorite

15:40 – 15:50 CEST

Debate: Are We Ready to Integrate ctDNA in Treatment Selection - YES

Debate Speaker: Jeanne Tie, MBChB FRACP MD – Peter MacCallum Cancer Centre

Favorite

15:45 – 15:55 CEST

Debate: Neoadjuvant Therapy in Locally Advanced Colon Cancer - YES

Debate Speaker: Jenny Seligmann, MBChB, PhD – University of Leeds

Favorite

15:50 – 16:00 CEST

Debate: Are We Ready to Integrate ctDNA in Treatment Selection - NO

Debate Speaker: Elena Elez, Sr., MD PhD – Vall Hebron University Hospital

Favorite

15:55 – 16:05 CEST

Debate: Neoadjuvant Therapy in Locally Advanced Colon Cancer - NO

Debate Speaker: Thierry André, MD – Hopital Saint Antoine

Favorite

16:00 – 16:10 CEST

Debate: Are We Ready to Integrate ctDNA in Treatment Selection - DISCUSSION

Panelist: Jeanne Tie, MBChB FRACP MD – Peter MacCallum Cancer Centre

Panelist: Elena Elez, Sr., MD PhD – Vall Hebron University Hospital

Favorite

16:05 – 16:15 CEST

Debate: Neoadjuvant Therapy in Locally Advanced Colon Cancer - DISCUSSION

Panelist: Jenny Seligmann, MBChB, PhD – University of Leeds

Panelist: Thierry André, MD – Hopital Saint Antoine

Favorite

16:15 – 16:40 CEST

Keynote Lecture: Single Cell Analysis and Transcriptomics

Keynote Speaker: Sabine Tejpar, MD PhD – University Hospitals Leuven / KU Leuven

Favorite

16:45 – 17:15 CEST

Break and Poster Viewing

Favorite

16:50 – 17:10 CEST

Poster Discussion Guided Tours - Group 10: Colorectal and Anal Cancers (PD-27, PD-28, PD-29)

Poster Discussant: Cathy Eng, MD, FACP, FASCO – Vanderbilt-Ingram Cancer Center

Favorite

16:50 – 17:10 CEST

Poster Discussion Guided Tours - Group 9: Colorectal Cancer III (PD-25, PD-26)

Poster Discussant: Sara De Dosso, MD – Medical Oncology Department, Oncology Institute of Southern Switzerland

Favorite

16:45 – 17:30 CEST

ESMO Lounge Session: Complex Clinical Trials in GI Cancers: Is the Pain Worth the Gain?

Session Chair: Deniz Can Güven, MD – Hacettepe University Cancer Institute

Session Chair: Rille Pihlak, MD, PhD – St Bart's Hospital

Speaker: Jenny Seligmann, MBChB, PhD – University of Leeds

Favorite

17:15 – 18:30 CEST

Session XVIII: Immune Mechanisms and Microbiome in GI Tumors

Chair: Sara De Dosso, MD – Medical Oncology Department, Oncology Institute of Southern Switzerland

Chair: Josep Tabernero, MD – Vall d’Hebron University Hospital

Favorite

17:15 – 17:23 CEST

SO-22: Gut microbiome composition as predictor of the efficacy of adding atezolizumab to first-line FOLFOXIRI plus bevacizumab in metastatic colorectal cancer: a translational analysis of the AtezoTRIBE study

Abstract Presenter: Federica Marmorino

Favorite

17:23 – 17:31 CEST

SO-23: The influence of the microbiome on the tumour-immune microenvironment in colorectal cancer

Abstract Presenter: Rachel Purcell

Favorite

17:31 – 18:00 CEST

Microbiome and Colorectal Cancer

Speaker: Elena Elez, Sr., MD PhD – Vall Hebron University Hospital

Favorite

18:00 – 18:10 CEST

LBA-4: Results from an expanded phase 1 trial of botensilimab (BOT), a multifunctional anti-CTLA-4, plus balstilimab (BAL; anti-PD-1) for metastatic heavily pretreated microsatellite stable colorectal cancer (MSS CRC)

Abstract Presenter: Andrea Bullock

Favorite

18:10 – 18:30 CEST

Resistance Factors to IOs

Speaker: Guillem Argiles, MD – Memorial Sloan Kettering Cancer Center

Favorite

18:30 – 19:15 CEST

Session XIX: Predicting and Managing Rare Toxicities in Patients With GI Cancers

Chair: Shouki Bazarbashi, MBBS – King Faisal Specialist Hospital and Research Center-Riyadh

Chair: Elena Elez, Sr., MD PhD – Vall Hebron University Hospital

Chair: Demetris Papamichael, MB BS FRCP – Bank of Cyprus Oncology Centre

Favorite

18:30 – 18:40 CEST

O-9: Health‑related quality of life associated with trifluridine/tipiracil in combination with bevacizumab in refractory metastatic colorectal cancer: An analysis of the phase 3 SUNLIGHT trial

Abstract Presenter: Gerald Prager, MD – Medizinische Universität Wien

Favorite

18:30 – 18:50 CEST

O-10: Health-related quality of life (HRQOL) in patients with advanced gastric, gastroesophageal junction, or esophageal adenocarcinoma cancer (GC/GEJC/EAC): 36-month results of CheckMate 649 nivolumab plus chemotherapy (N+C) versus chemo (C)

Abstract Presenter: Markus Moehler, MD – Universitätsmedizin Mainz

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18:50 – 19:15 CEST

Keynote Lecture: Toxicity Management - Nausea and Vomiting

Speaker: Matti Aapro, MD – Clinique de Genolier

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